Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients

Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system.These proteins can be detected using the quaking-induced conversion assay.Compared with other bioassays, this assay is extremely sensitive and was used in the present study to turbosound ts-18sw700/8a determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy.Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in vetality twist and lick non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity.